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Table of Contents Revenues in 2005 resulted primarily from our research collaborations with ALZA and Pfizer. Revenues in 2004 resulted primarily from our research collaborations with ALZA and Pfizer, as well as our federal grants under the National Institute of Standards and Technology, Advanced Technology Program, or ATP, and Small Business Innovation Research, or SBIR, programs. Revenues in 2003 resulted primarily from our ALZA collaboration as well as our ATP and SBIR Phase 1 2 grants. The decrease in revenues in 2005 compared to 2004 was primarily the result of the following factors: $3.2 million decrease in revenues due to the conclusion of the ALZA collaboration in March 2005; $1.1 million decrease in revenues due to timing differences in the recognition of revenue under the Pfizer agreement and its conclusion in November 2005; $1.0 million decrease in grant revenues due to the conclusion of the ATP and SBIR grants in October 2004 and February 2005, respectively; and partially offset by $0.1 million increase in revenues due to the commencement of our Astellas collaboration in December 2005. The increase in revenues in 2004 compared to 2003 was primarily the result of a $3.7 million increase in revenues from the Pfizer collaboration due to its commencement in the fourth quarter of 2003. We expect revenues to fluctuate in future years primarily resulting from the: timing of certain development milestone payments payable under the terms of our Astellas collaboration; and extent to which we enter into additional collaborations. Research and Development Expenses Of the total research and development expenses for the years ended December 31, 2005, 2004 and 2003, the costs associated with research and preclinical and clinical development activities approximated the following.
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To the best of your knowledge, have you ever been told by a doctor or any other health care provider, that you have, may have or had any of the following: 1. Hypertension or high blood pressure Yes No 2. Heart murmur Yes No 3. Heart attack Yes No 4. Stroke Yes No 5. Blood clot to the lung pulmonary embolism ; Yes No 6. Blood clot in the leg and or phlebitis Yes No 7. Chronic lung disease Yes No - 11, for example, tenoretic atenolol.
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Convenience of access In every case study, injecting drug users were able to access services in a variety of ways and at various times. Outreach is the most common method for providing convenient access to education, needle and syringe exchange and other services; while easy access to services for injecting drug users in fixed sites, for example, near building entrances or separate entrances for injecting drug users, increases their attractiveness. For needle-syringe programmes, the use of secondary exchange increases convenience as injecting drug users can acquire injecting equipment through friends, drug dealers or at shooting galleries. For secondary exchange to be successful, good working relationships are needed with the law enforcement services, and monitoring is required to ensure that injecting drug users are receiving appropriate information and education from secondary exchangers or peer educators. exceptions such as backpack buprenorphine distribution in India and methadone buses in Germany and the Netherlands. The number and location of clinics is vital to ensure convenience, for example, the Hong Kong SAR programme. Involvement of injecting drug users operations as vital in reaching injecting drug users. Even with the Hong Kong SAR methadone programme, clients are involved through surveys which lead to changes to services. Regular interactions based on respect and friendliness between injecting drug users and programme staff is a factor in achieving high coverage. Working with groups of active and former users has been undertaken in Salvador, Dhaka and Rajshahi and is being considered in Hong Kong SAR. Greater involvement of injecting drug users in appropriate structures such as advisory bodies, injecting drug user groups or as programme staff is likely to result in sustainable programmes. Management issues Technical assistance and training for managers, and on-going training, or retraining of staff, especially those working face-to-face with injecting drug users is crucial. Also of importance are effective supervision, ability to deal with problems, regular team meetings and on-going training opportunities, resulting in staff retention, which in turn attracts regular attendance by injecting drug users. Also, orclinicstaffinthecaseof Hong Kong SAR. Even in Dhaka, managers and supervisors work with more than 50 paid peer outreach workers. A balance between control or supervision of outreach or clinical work, and trust of outreach and clinical staff to perform their for programme areas, including advocacy and outreach, may be particularly suitable to South Asia and South-East Asia, where active injecting drug users employed as.
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